Preliminary Interview – Medical HistoryDrugs that can alter gut microbiotaUse in the last three months of:
▪ Antimicrobial drugs
▪ Immunosuppressant agents
▪ Chemotherapy
Daily use for over three months:
▪ Proton pump inhibitors
Disorders potentially associated with the disruption of gut microbiota:
▪ Personal history of chronic gastrointestinal disease, including functional gastrointestinal disorders; inflammatory bowel disease; celiac disease; other chronic gastroenterological diseases or recent abnormal gastrointestinal symptoms (e.g., diarrhea, hematochezia, etc.)
▪ Personal history of cancer, including gastrointestinal cancers or polyposis syndrome, and first-degree family history of premature colon cancer
▪ Personal history of systemic autoimmune disorders
▪ Obesity (body mass index > 30) and/or metabolic syndrome/diabetes
▪ Personal history of neurological/neurodegenerative disorders
▪ Personal history of psychiatric/neurodevelopmental conditions
Know history or risk behaviors for infectious disease
▪ History of HIV, hepatitis B or C viruses, syphilis, human T-lymphotropic virus I and II
▪ Current systemic infection
▪ Use of illegal drugs
▪ High-risk sexual behavior
▪ Previous tissue/organ transplant
▪ Recent hospitalization or discharge from long-term care facilities
▪ High-risk travel
▪ Needle stick accident in the last six months
▪ Body tattoo, piercing, earring, acupuncture in the last six months
▪ Enteric pathogen infection in the last two months
▪ Acute gastroenteritis with or without confirmatory test in the last two months
▪ History of vaccination with a live attenuated virus in the last two months
Blood testing
▪ Complete blood cell count
▪ Liver enzyme (Aminotransferases)
▪ Bilirubin
▪ Creatinine
▪ C-reactive protein
▪ Serology for Hepatitis virus (HAV, HBV, HCV, HEV) and Human immunodeficiency virus (HIV)
Stool testing
▪ Clostridium difficile
▪ Giardia lamblia, Cryptosporidium spp, Isospora and Microsporidia
▪ Protozoa and helminths and parasites (including Blastocystis hominis and Dientamoeba fragilis)
▪ Antibiotic-resistant bacteria
▪ Common enteric pathogens, including Salmonella, Shigella, Campylobacter, shiga toxin-producing Escherichia coli, Yersinia, and Vibrio cholerae
▪ Norovirus, rotavirus, adenovirus
▪ Helicobacter pylori fecal antigen
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